In 2017, a group of Dutch allergists, dermatologists, primary care physicians and allergy researchers, developed an allergy management support system (AMSS) to support GPs with the diagnosis and management of allergic patients.7, 23 Depending on the answers to a disease history questionnaire completed by the patient, and specific-IgE test outcomes, the physician is guided on diagnostic classification and severity, and receives management recommendations based on primary care and specialists' allergy guidelines complemented with clinical knowledge and expert opinion. This evidence concerns the gene IGHE and allergic disease.