INS and type 1 diabetes mellitus: Autoantibodies including islet cytoplasmic autoantibodies (ICA), antibodies to insulin (IAA), the 65 kD form of glutamate decarboxylase (GADA), and the protein tyrosine phosphatase IA2 (IA2A) can be used to identify the onset of or risk of developing T1DM in more than 80% of the patients [108, 109].