A comparison of WT, Gab2−/−, Gab3−/−, and Gab2/3−/− mice showed that maximal Lcn-2 increase was observed in double knockout mice (average of 26-fold), whereas mice with rectal prolapse had high Lcn-2 levels, but high Lcn-2 levels did not predict rectal prolapse. Here, GAB3 is linked to Rectal prolapse.