The most interesting set of connections are the links between the WS genes BAZ1B, EIF4H, GTF2I, GTF2IRD1, MLXIPL, and STX1A, and the domestication candidates PRKG2, CACNA1C, NRXN1, SNAP29, PPP2CA, RPL3, EIF2S2, RNPC3, SNRPD1, SF3B1, and POLR1E. Specifically, GTF2I has been related to cognitive problems and craniofacial abnormalities in WS (Morris et al., 2003; Tassabehji et al., 2005). The gene discussed is GTF2IRD1; the disease is Werner syndrome.