PSEN1 and Alzheimer disease: For example, natural polyphenols such as curcumin can bind Aβ (1–42) and block its fibril formation and aggregation (Yang et al., 2005); resveratrol is capable of changing the oligomeric conformation and attenuate the cytotoxicity of Aβ (Feng et al., 2009); epigallocatechin-3-gallate is able to reduce the level of Aβ in brain and protect the mitochondrial function of neurons in the amyloid precursor protein (APP) and presenilin-1 (PS1) double transgenic AD mice (Dragicevic et al., 2011).