TNF and neoplasm: It has been shown that nobiletin has exhibit biological effects including anti-inflammatory, anti-tumor and neuroprotective effects.(15–20) Lin et al.(16) reported that nobiletin decreased LPS-induced production of prostaglandin E2 and proinflammatory cytokines including IL-1α, IL-1β, TNF-α and IL-6 in mouse J774 macrophage cells.