Consistent with our data, it was reported that quercetin, which flavonoid and structurally similar to fisetin, regulates the SENS2 signaling and induces apoptosis by inducing the generation of intracellular ROS and AMPK/p38 signaling pathway.(27) It suggests the possibility of SESN2 as a therapeutic target for cancer treatment. Here, SESN2 is linked to cancer.