Fisetin-induced apoptosis of human oral cancer cells was through ROS production and mitochondria-dependent signaling pathways.(25) Fisetin also induced apoptosis through p53-mediated upregulation of death receptor 5 expression in human renal carcinoma cells.(26) However, the molecular targets for fisetin-induced apoptosis in HNCCs are not yet known precisely. The gene discussed is TNFRSF10B; the disease is renal carcinoma.