CCL5 and colorectal carcinoma: Macrophage repolarisation therapy targeting the CCL5–CCR5 axis has been described in preclinical and clinical analyses for metastatic CRC.46,114–116 The chemokine effects of CCL5 on the migration of myeloid cells seems to have a minor role in this efficacy; rather, macrophage polarisation, with immediate effects on the production of interferon and reactive oxygen species, mediates these anti-tumoural effects and combination trials with checkpoint inhibitors are currently underway (NCT03631407 and NCT03274804).