To more stringently assess the impact of NK cell loss on regression of lung adenocarcinoma cells following p53 reactivation, we also transplanted KPrLG cells into C57BL/6: Rag1-/-; Il2rg-/- mice that additionally lack the common gamma chain (γc) that is necessary for NK cell development and signaling through multiple cytokine receptors. The gene discussed is IL2RG; the disease is lung adenocarcinoma.