TP53 and lung adenocarcinoma: To better understand p53-mediated immune surveillance in this model, here we develop orthotopically transplantable lung adenocarcinoma cell lines from KrasLA2/+, Trp53LSL/LSL,Rosa26CreER/CreER (KPr) tumors where the endogenous Trp53 locus can be restored to a wild-type state after engraftment into the mouse lung.