To more stringently assess the impact of NK cell loss on regression of lung adenocarcinoma cells following p53 reactivation, we also transplanted KPrLG cells into C57BL/6: Rag1-/-; Il2rg-/- mice that additionally lack the common gamma chain (γc) that is necessary for NK cell development and signaling through multiple cytokine receptors. This evidence concerns the gene RAG1 and lung adenocarcinoma.