For females, there was an IVW estimated 0.80 (95% CI 0.63 to 1.01) OR for asthma per unit increase in log SHBG when using IV combination A, whereas in males there was an IVW estimated 0.95 (95% CI 0.77 to 1.18) OR for asthma. The gene discussed is SHBG; the disease is asthma.