Serial cross-sectional models of SHBG, TT and BT in males revealed little evidence of an association between SHBG and asthma (model 1 in online supplementary table S1 appendix A1), but a consistent inverse association between TT and BT on asthma after 11.8 years (model 1 in online supplementary tables S2 and S3 appendix A1). The gene discussed is SHBG; the disease is asthma.