In line with these findings, Reho et al. recently reported that CPI-17 protein was downregulated in mesenteric arteries concordant with reduced force generation to depolarization, Ca2+ increase, and phenylephrine (PE) in a mouse lipopolysaccharide (LPS) model of sepsis (17), indicating that downregulation of smooth muscle CPI-17 may play a role in vasodilatory shock. This evidence concerns the gene PPP1R14A and Sepsis.