Neuroimaging techniques consistently showed both aberrant frontal brain anatomy and function as well as an effect of COMT Val/Met genotype in 22q11DS (van Amelsvoort et al., 2001, 2008; Gothelf et al., 2005; Zinkstok and van Amelsvoort, 2005; Kates et al., 2006; Howes et al., 2012; Shashi et al., 2012; van Beveren et al., 2012; Jonas et al., 2014). This evidence concerns the gene COMT and 22q11.2 deletion syndrome.