Recent data reported that VEGFA could promote tumor development and growth in a preclinical model of HCC and suggested VEGFA genomic amplification in HCC tumor tissues as a predictive biomarker for sorafenib based on results showing survival of patients with HCC who did not receive sorafenib was independent of VEGFA status in tumor tissue, whereas markedly improved survival was seen in the VEGFA-amplification group compared with the non- amplification group in sorafenib-treated patients [6, 8]. The gene discussed is VEGFA; the disease is neoplasm.