The beneficial effects of empagliflozin shown in this study include: (1) reduced systemic blood pressure, (2) improved renal function, (3) improvement in left atrial dilatation, (4) attenuated intra-cardiac fibrosis, (5) improved incline and decline dP/dt of left ventricle, and (6) modulated genes related to fatty acid metabolism (PPARα and ACADM) and restored upregulated genes in HF. The gene discussed is ACADM; the disease is hydrops fetalis.