Further study in mouse model demonstrated that downregulated cGAS-STING pathway led to decreased tumor-infiltrating CD3+ CD8+ T cells by reducing the expression of downstream genes of type I IFN such as chemokine (C-X-C motif) ligands 9 and 10 (CXCL9 and CXCL10) [50]. The gene discussed is CXCL9; the disease is neoplasm.