Based on the observation that several CTL-defined epitopes have been mapped to EBV latent membrane proteins (LMPs) restricted with HLA-A2, HLA-A11, or HLA-A24 antigen, Kanno et al. reported a significantly lower frequency of the HLA-A*0201 allele in Japanese patients with ENKTL compared to healthy controls and suggested that the HLA-A*0201-restricted CTL responses to LMPs in EBV-infected tumor cells may function in vivo to suppress the development of overt lymphoma [118]. The gene discussed is HLA-A; the disease is neoplasm.