Echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase (ALK) fusion proteins, which also initiate Ras/Raf/MEK/ERK and PI3K/Akt/mTOR pathways, are emerging therapeutic targets in NSCLC [21]. The gene discussed is EML4; the disease is non-small cell lung carcinoma.