Representative positive and negative stains of cyclin A and DUB3 in NSCLC tissues and adjacent lung tissues are shown in Figure 7A. Moreover, a significant positive correlation (R = 0.3333, p = 0.018) between DUB3 and cyclin A protein levels was observed in these NSCLC tissues (Figure 7D), in which 80% (28 of 35) of the tumor samples with high DUB3 expression also exhibited high cyclin A. Thus, these results in NSCLC tissues support our proposed mechanism based on cell culture experiments that expression of DUB3 contribute to maintain cyclin A levels. The gene discussed is CCNA2; the disease is non-small cell lung carcinoma.