In particular, although a companion immunohistochemical method for PD-L1 expression analysis has been approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for patients with advanced non-small cell lung carcinomas (NSCLC) as a specific requirement for treatment with pembrolizumab, the predictive value of this preliminary assay remains questionable [4,5]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.