MAPT and early-onset autosomal dominant Alzheimer disease: To confirm that these effects are due to specific inhibition of HDAC6 by Tubastatin A, Tg4510 mice can be crossed with Hdac6 knockout mice in order to examine the effects on memory formation and tau levels, In another study of an Alzheimer’s disease mouse model treatment with ACY-1215 and Tubastatin A, both led to improvement in the behavioral assays as well as changes in amyloid β levels, decrease in phosphorylation of tau and increase in α-tubulin acetylation [40].