In an amyloid precursor protein/presenilin 1 (APP/PS1) mouse model, treatment with the HDAC6 inhibitor ACY-738 resulted in improvement of axonal transport rates, decrease in phosphorylation of tau and increase in α-tubulin acetylation, accompanied by improvement in amyloid pathology as well as contextual learning and memory [23]. This evidence concerns the gene HDAC6 and amyloidosis.