In a study of cortical neurons from a Rett syndrome MECP2T158A mouse model and of patient fibroblasts, it was found that the cortical neurons of the MECP2-deficient mice and the patient fibroblasts had increased levels of HDAC6 protein expression and reduced levels of acetylated α-tubulin and treatment with Tubastatin A resulted in increased levels of acetylated α-tubulin [48]. This evidence concerns the gene HDAC6 and Rett syndrome.