HDAC1 and hepatocellular carcinoma: Another study demonstrated a H2O2-dependent downregulation of E-cadherin in hepatocellular carcinoma cells that was described as a result of a hypermethylation in the promoter region upon the recruitment and ROS-dependent upregulation of histone deacetylase 1 (HDAC1) and DNA methyltransferase 1 (DNMT1).