However, this result was challenged by other studies demonstrating the pathogenic role of TRPV1 by gene-deleted mice exhibiting less severe DSS-induced colitis, concluding that inflammatory mediators activate the TRPV1 receptor and induce neurogenic inflammatory components by releasing SP, neurotensin, vasoactive intestinal polypeptide and galanin [64,69]. Here, TRPV1 is linked to colitis.