Like other MMPs, MMP-9 is a member of the broad ECM remodeling network [19,20] and plays a crucial role in physiological processes such as proliferation, differentiation, and wound healing, but also in tumor progression, metastasis, and angiogenesis [2,21] due to its ability to efficiently degrade (amongst others) gelatin, collagens (IV, V, VII, X, XIV), elastin, aggrecan, and fibronectin [22]. This evidence concerns the gene ACAN and neoplasm.