Almost 5000 proteins were profiled, and 177 proteins were selected based on altered ZNF143 expression (more than 1.2-fold or less than 0.83-fold in sh-ZNF143 cells compared to that in sh-Control controls, with a significant p-value), and were used for pathway analysis in breast cancer cells (Figure 5A and Supplementary Table S2). The gene discussed is ZNF143; the disease is breast carcinoma.