To explain how p53 is degraded in a proteasome-dependent manner in MCF7 sh-ZNF143 cells and how ZNF143 expression is linked to proteasome regulation through p53 in breast cancer cells, we conducted mass spectrometry to profile and identify differentially expressed proteins in MCF7 sh-Control and sh-ZNF143 cells (NCC Omicscore). Here, ZNF143 is linked to breast cancer.