The chronic stress and mTOR-dependent inhibition of autophagy can lead to the accumulation of tau aggregates in P301L-tau-expressing mice and cells, which is validated by molecular, pharmacological, and behavioral analysis [71], suggesting that dys-regulated generation, phosphorylation, and aggregation of tau might be the key events for triggering neuronal degeneration in AD. Here, MAPT is linked to Alzheimer disease.