While Dnmt2 KO mice are viable and grossly normal [69], recent evidence suggests that DNMT2/TRDMT1-dependent RNA modifications play an important role in intergenerational transmission of paternally acquired metabolic disorders to offspring by regulating the sperm small RNA expression profile, including tRNA- and rRNA- derived small RNAs [71]. The gene discussed is TRDMT1; the disease is Other metabolic disease.