In fact, the association of high mutational burden and CIN with short PFS remained as a trend in multivariable Cox models that combined mutational burden, CIN, co-occurring CCND1 and CDKN2A mutations, tumor site, and HPV status (with p = 0.079 and p = 0.059, respectively). The gene discussed is CDKN2A; the disease is cervical squamous intraepithelial neoplasia.