Interestingly, the uncontrolled regulation of these molecular mechanisms has also been related to the variability of genes (namely, CFH, ARMS2/HTRA1, IL-6, IL-8, COL8A1, SLC16A8, and VEGFA) associated with a specific susceptibility to exudative AMD [1]. The gene discussed is COL8A1; the disease is age-related macular degeneration.