Whereas many aspects of impaired glucose metabolism (including pathophysiology of insulin sensitivity) and its relationships to BD morbidity, course and treatment remain to be elucidated, long-term complications (in both somatic and psychiatric health) of IR/2TD point to the necessity of detection of impaired glucose metabolism at the stage of insulin resistance, which may appear 10–20 years before the final diagnosis of T2D [15,16,17]. The gene discussed is INS; the disease is Insulin resistance.