Insulin resistance, in other words, reduced insulin sensitivity is a pathological state characterized by a lack of physiological response of peripheral tissues to insulin action, which may lead to various disturbances (i.e., dyslipidemia, hypertension, T2D, abdominal obesity, hypercoagulability and defects in the fibrinolytic system, fatty liver, and an increased risk of coronary heart disease) [20]. Here, INS is linked to digestive system neoplasm.