Interestingly, the hybrid EMT (EpCAM+/Vim-GFP+) tumor cells but not mesenchymal-like (EpCAM−/Vim-GFP+) cells initiated metastatic tumor growth in the lung [96]; these observations indicated that the hybrid EMT PC cells possess lineage plasticity, which mediates MET transition and the subsequent formation of macrometastasis. Here, EPCAM is linked to neoplasm.