Using mice with prostate-specific PTEN−/− and KRasG12D expression together with a vimentin–GFP reporter, Ruscetti et al. reported epithelial tumor cells (EpCAM+/Vim-GFP−), hybrid EMT (EpCAM+/Vim-GFP+) tumor cells, and mesenchymal-like (EpCAM−/Vim-GFP+) tumor cells [95,96] which likely resulted from a full EMT transition [95]. This evidence concerns the gene PTEN and neoplasm.