MAPK14 (p38 MAPK) pathway: despite the anti-proliferative and tumor suppressor activity of MAPK14 in some tissues [110], these kinases have an important role in the regulation of CRC cellular proliferation and differentiation, apparently by activating transcription factors such as STAT1 (signal transducer and activator of transcription factor 1) and protecting cells from apoptosis [109]. This evidence concerns the gene MAPK14 and colorectal carcinoma.