SESN1 and cancer: Furthermore, a number of genes whose expressions are influenced by the RS diet are regulators of tumor cell cycle and proliferation, such as PLK2 [31], FOXP1 [32], PIK3R1 [33], DDIT4 [34], SESN1 [35], and ZBTB16 [36], or regulators of apoptosis, such as SOX4 [37], FOXO3 [38], and TP53INP1 [39], suggesting that RS or dietary manipulation may act synergistically with anti-cancer therapy to improve the treatment of cancer patients.