GHRL and colitis: In the gut, animal studies have shown that obestatin accelerates the healing of chronic gastric ulcer evoked by acetic acid [296] (Figure 3), attenuates mesenteric ischemia/reperfusion-induced oxidative injury of the ileum and lung [297], inhibits the development of acetic acid-induced colitis [298], reduces the severity of experimental colitis evoked by trinitrobenzene sulfonic acid [299] and accelerates the healing of acetic acid-induced colitis in rats [300].