However, (adenovirally-mediated) adiponectin overexpression was capable of improving muscle regeneration in both adiponectin knockout mice and in angiotensin II infused mice (to mimic chronic heart failure condition or aging conditions) [58], suggesting that while adiponectin may not be a primary mediator of skeletal muscle regeneration, its presence or absence can significantly affect the regenerative process. This evidence concerns the gene ADIPOQ and congestive heart failure.