BCHE and Alzheimer disease: Inhibiting both enzymes produces an increment of the ACh concentration in the cholinergic synapses that show a symptomatic efficacy in AD treatment; therefore, competitive cholinesterase inhibitors (ChEIs), e.g., galanthamine or rivastigmine as well as non-competitive ChEIs, e.g., tacrine or donepezil are clinically applied to alleviate the neuromuscular symptoms of AD [14].