In 4 individuals with MWO, authors have detected mutations in six genes, one of which is ARHGAP28. A missense mutation in the ARHGAP28 gene, which converts the threonine 31 residue to serine (T31S), reduced the ARHGAP28 expression, elevated RhoA and ROCK activities, resulting in cerebral vasoconstriction, spasm, and migraine, as well as an increase in the intensity of inflammatory reaction in the brain [127]. The gene discussed is ARHGAP28; the disease is migraine disorder.