Because the loss of intraepidermal nerve fibers (IENFs) in the peripheral nerve is known to be related with a pathological finding in cancer patients receiving chemotherapy [30], we investigated whether LOHP can induce the denervation of peripheral nerves in distal foot skin by immunostaining nociceptive IENFs with anti-protein gene product 9.5 (PGP9.5) antibody (Figure 2C). The gene discussed is UCHL1; the disease is cancer.