Pharmacological activation of PINK1-Parkin-related mitophagy has been reported to improve mitochondrial function in animal models of Alzheimer’s disease [44,45], while overexpression of Parkin has been reported to protect retinal ganglion cells in an experimental glaucoma rat model [15] and to improve cardiac function in rats with myocardial infarction [46] via activation of mitophagy. The gene discussed is PINK1; the disease is early-onset autosomal dominant Alzheimer disease.