PRKN and early-onset autosomal dominant Alzheimer disease: Pharmacological activation of PINK1-Parkin-related mitophagy has been reported to improve mitochondrial function in animal models of Alzheimer’s disease [44,45], while overexpression of Parkin has been reported to protect retinal ganglion cells in an experimental glaucoma rat model [15] and to improve cardiac function in rats with myocardial infarction [46] via activation of mitophagy.