EGFR and cancer: Quinoxalines are considered as an important basis for anti-cancer drugs as they are proved to be selective adenosine triphosphate (ATP) competitive inhibitors in many kinases [5] for example: vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), proto-oncogene non-receptor tyrosine-protein kinase (Src), c-Met proto-oncogene (c-Met kinase), epidermal growth factor receptor\human epidermal growth factor receptor (EGFR/HER-2), Janus kinase receptor (JAK-2), FMs-related tyrosine kinase 3 (FLT-3) and cyclin dependent kinase (CDK1,2,4,6) [6].