Even though, in our setting, the effects of KRX-C7 on DCM could be a consequent of glycaemic metabolism and insulin sensitivity restoration, the known ability of GRK2 to regulate NF-κB suggests that the inhibition of the kinase through KRX-C7 could have a direct effect on DCM related inflammation. The gene discussed is GRK2; the disease is familial dilated cardiomyopathy.