GRK2 is the long-recognized mechanism for agonist-activated G protein-coupled receptor (GPCR) desensitization and internalization [5,6]; increased GRK2 levels and/or activity have important implications in many cardiovascular conditions, such as myocardial ischemia, hypertrophy, and hypertension [7,8]. This evidence concerns the gene GRK2 and Hypertension.