In the present study, 13 variants distributed in four genes were detected in the stool samples of patients with CRC or polyps (p.R876*, p.R1114* and p.R1450* in APC; p.G12S, p.G12A, p.G12D, p.G12V, p.G13D and p.A146T in KRAS; p.R213* and p.R175H in TP53; p.E545K and p.T1025A in PIK3CA). This evidence concerns the gene PIK3CA and colorectal carcinoma.