Dysplastic nevi have a broader spectrum of driving mutations than benign nevi—while most of the intermediate lesions display the BRAFV600E mutation [9,27], there is a subset of dysplastic nevi harboring different MAPK pathway activating mutations, including NRASQ61K/R and two other BRAF pathogenic mutations, i.e., BRAFV600K and BRAFK601E [9]. The gene discussed is BRAF; the disease is dysplastic nevus.