Mutations of NRAS, KRAS, and HRAS occur in 10–25%, 2%, and 1% of non-uveal melanoma, respectively, including those arising both on sun-exposed and sun-unexposed skin, mucosal, and acral melanomas [92]; in contrast, RAS mutations are rarely observed in uveal melanomas [93]. Here, NRAS is linked to acral lentiginous melanoma.