NRAS-mutated melanomas are significantly thicker than wild-type tumors; accordingly, a significant association between NRAS mutation and higher Clark’s level of invasion has been found [95,96], suggesting a putative role of this mutation as an adverse prognostic factor; however, the percentage of ulcerated melanomas is low among NRAS-mutated samples [97,98]. The gene discussed is NRAS; the disease is melanoma.