GRM7 and Anxiety: In a stress-sensitive Wistar Kyoto rat strain, which spontaneously exhibits visceral hypersensitivity as well as anxiety-like behaviors, the potent, selective and brain permeant mGlu7 negative allosteric modulator, ADX71743, normalized visceral hypersensitivity and reduced stress-induced anxiety-like behavior by modulating both centrally and peripherally located mGlu7 receptors [203].