Recent literatures of the significant association between CDO1 methylation and poor prognosis have been reported in breast [15, 16], esophageal [17, 18], renal cells carcinoma [22], HPV associated malignancies [29], prostate cancer [30], gallbladder cancer [21], and colorectal cancer [20]. The gene discussed is CDO1; the disease is hereditary clear cell renal cell carcinoma.