For instance, increased expression of genes associated with inflammation (Mmp13, Il6, etc.), cellular senescence (P21, Serpine1, etc.), and cell apoptosis (Dapk1, Casp4, etc.)were observed in ACLT-induced osteoarthritis joints, and the expression levels of most of these genes were diminished upon YAP or FOXD1 treatment. This evidence concerns the gene SERPINE1 and osteoarthritis.