Tumour‐associated macrophages are one of the widely found host immune cells in the tumour microenvironment involved in different cellular events to facilitate metastasis.6 In our study, we found ZNF143 reduced colon cancer cells secrete some factors including IL‐8, potentially differentiated monocytes into macrophages with increased expression of macrophage markers IL‐6 and CD206 (Figure 6), suggesting its role in intercellular communication with immune cells to set up an environment for tumour progression to metastasis. This evidence concerns the gene IL6 and colonic neoplasm.