Furthermore, the expression of the human ZNF143 gene by transfecting a plasmid‐encoding full‐length human ZNF143 (pFLAG‐CMV‐hZNF143FL) reversed these effects according to RT‐PCR (Figure 1G), implying that the transcription of IL‐8 may be regulated by ZNF143 in colon cancer cells. This evidence concerns the gene CXCL8 and malignant colon neoplasm.