CXCR1 and cancer: Within the tumour microenvironment, IL‐8 signalling is initiated by binding of its G‐protein‐coupled receptors CXCR1/2.33, 39 To examine whether ZNF143 expression affects on IL‐8 signalling in cancer cells, we examined the mRNA expression of CXCR1/2 (Figure 5A,B).