Whereas, DSPP‐MMP20 expression in the normal and neoplastic breast, colon and cervix epithelial suggests that these epithelia function as highly metabolic tissue, expression in thyroid and prostate neoplasia with minimal expression in their normal counterparts casts MMP20‐DSPP cognate pair as potential diagnostic and prognostic markers for neoplasm in these tissues. This evidence concerns the gene MMP20 and neoplasm.