Although reports on the expression and potential role of DSPP in the biology of a number of human epithelial cancers have mounted in recent years,22, 23, 30, 31, 32, 33 there only have been sporadic reports on the expression of MMP20 in specific cancers until recently.9, 17 Our current report therefore represents the first on a survey of the expression profile of MMP20 in an array of various notable human epithelial neoplasms. Here, MMP20 is linked to cancer.