In this cross-sectional analysis, people with NWCO (by WC, by WHtR and by WHR) had a higher risk of hypertension (HP), diabetes, insulin resistance (IR), decreased insulin sensitivity (DIS), low high-density lipoprotein (HDL) and elevated triglyceride (TG) compared with people who had normal weight and no central obesity. The gene discussed is INS; the disease is diabetes mellitus.