CRC cell lines (Moser, HCT-116, HT-29, HCA-7, HCT-15, Caco2) revealed a similar trend, although miR-21 levels and 15-PGDH mRNA expression were not significantly negatively correlated (Fig. 1e, r = −0.62, P = 0.19). Here, HPGD is linked to colorectal carcinoma.