STAT3 and colorectal neoplasm: To determine the molecular mechanism by which tRXRα expression in inflammatory cells promotes the growth of colorectal tumor through the IL-6-STAT3 pathway, we prepared bone marrow-derived macrophages (BMDMs) from Tg-tRXRα mice (tRXRα-BMDMs) and the corresponding control wild-type mice (Supplementary Fig. 4a).