In agreement with enhanced STAT3 activation, cell invasion assays showed that the invasion of colon cancer cells was significantly increased when they were cultured with CM from tRXRα-BMDMs (Fig. 5i) or co-cultured with THP-1 cells expressing tRXRα but not RXRα (Supplementary Fig. 5c). The gene discussed is STAT3; the disease is colonic neoplasm.